Those treated with an extract containing both compounds experienced a significant reduction in pain compared to those who received only THC extract . CBD has also shown antidepressant-like effects in several animal studies . The placebo, a 150-mg dose of CBD, and a 600-mg dose of CBD had little to no effect on anxiety . In one Brazilian study, 57 men received either oral CBD or a placebo 90 minutes before they underwent a simulated public speaking test. The researchers found that a 300-mg dose of CBD was the most effective at significantly reducing anxiety during the test.